The first Human hormone product by Recombinant DNA technology is

Concept-

• In genetic engineering, we can break the DNA molecule at two desired places with the help of endonuclease.
• And then insert it in another DNA molecule at the desired place.
• The new DNA molecule is called recombinant DNA.
• Genetic engineering can be used to improve the quality of human life.

Explanation-

• The first genetically engineered insulin obtained by recombinant DNA technique with the help of E-Coli was developed by the American firm, Eli-Lilly on 5 July 1983.
• Insulin is used for diabetes.
• Insulin consists of two short polypeptide chains: chain A and chain B, that are linked together by disulfide bridges.
• Eli Lilly an American company prepared two DNA sequences corresponding to A and B, chains of human insulin, and introduced them in plasmids of E. coli to produce insulin chains.
• Chains A and B were produced separately, extracted, and combined by creating disulfide bonds to form human insulin. 

Therefore the first Human hormone product by Recombinant DNA technology is insulin.

Additional InformationEstrogen

• Estrogens produce wide-ranging actions such as stimulation of growth and activities of female secondary sex organs, development of growing ovarian follicles, the appearance of female secondary sex characters (e.g., the high pitch of voice, etc.), mammary gland development.
• Estrogens also regulate female sexual behavior.

Progesterone

• Progesterone supports a pregnancy.
• Progesterone also acts on the mammary glands and stimulates the formation of alveoli (sac-like structures which store milk) and milk secretion. 

Thyroxine

• Thyroxine is the hormone secreted by the thyroid gland.