Stereochemistry of SN2 reaction involves:  

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DSSSB PGT Chemistry (Female) Official Paper (Held On: 06 Jul, 2018 Shift 1)
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  1. Retention 
  2. Inversion 
  3. Racimisation with retention 
  4. Racimisation with inversion 

Answer (Detailed Solution Below)

Option 2 : Inversion 
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CONCEPT:

Stereochemistry of SN2 Reactions

  • SN2 Reaction Mechanism: The SN2 (bimolecular nucleophilic substitution) reaction involves a single-step mechanism where the nucleophile attacks the electrophilic carbon from the side opposite to the leaving group, leading to the formation of a transition state and then the product.
  • Backside Attack: Since the nucleophile attacks from the side opposite to the leaving group, a backside attack occurs, which flips the configuration of the carbon center.
  • Stereochemical Outcome: The SN2 reaction leads to an inversion of configuration at the chiral center, also known as "Walden inversion".

EXPLANATION:

  • In an SN2 reaction, if the reactant molecule has a chiral center, the reaction will result in an inversion of the configuration at that chiral center.
  • This inversion happens because the nucleophile must approach from the side opposite to the leaving group, effectively flipping the spatial arrangement of the substituents around the chiral carbon.
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  • This process is different from racemization (which produces a 50:50 mixture of both enantiomers) and retention (which maintains the original configuration).

The correct option is 2) Inversion.

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